Tumour genetics

Tumour genetics is a growing field of oncological diagnostics

which is concerned with detecting acquired genetic alterations (somatic mutations). These somatic mutations can bear a direct relationship to the genesis of the disease. Hence, detecting specific gene alterations (molecular genetic analyses) or chromosomal aberrations typical of the disease (cytogenetics and molecular cytogenetics) are frequently crucial for diagnosis, prognosis and therapeutic planning.
Genetic characterisation is increasingly being used in new classification systems defined by molecular genetics that were previously understood as heterogeneous tumour diseases. Genetic stratification allows prognostically relevant subgroups to be defined.
A better understanding of the molecular pathological carcinogenesis mechanisms has led to the development of various targeted forms of therapy which are often much more effective and have fewer side effects than standard chemotherapy. Detecting the underlying molecular dysfunction is a prerequisite for the indication of these complex therapies. Sensitive tumour genetic monitoring techniques are increasingly being applied in the course of the disease for post-therapy evaluation of remission.

Sampling / shipping

  • Bone marrow sample (min. 10 x 106 mononuclear cells) : 5 – 10 ml heparinised bone marrow aspirate+
    Duration*: 8 – 10 days
  • Leukemia blood (blast count ≥ 20 %) :  5 – 10 ml heparinised peripheral blood+
    Duration*: 8 – 10 days

Request form: Cancer genetics

Duration* = Processing time after arrival of the sample in the laboratory

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